“It’s unfortunate biologically we have to sleep.”

I’m obsessed with speed. I’m always asking myself, ‘Why can’t we do things faster? Why can’t it happen more efficiently? Why is this requiring three meetings instead of one?’

Listen to your customers, but don’t always build exactly what they’re telling you. This is a really key distinction around building enterprise software.

You want to find the really crazy but still somewhat reasonable outliers within the customer ecosystem.

You intentionally start small, because you will not be able to compete with an incumbent… because the incumbent is always going to go for the full solution.

The chance of failure is almost always better than the guarantee of never knowing.

You’ll learn more in a day talking to customers than a week of brainstorming, a month of watching competitors, or a year of market research.

What happens to the Microsofts, Oracles and IBMs of the world is that when they get big enough, they don’t think they need to bring that same level of focus and energy to the end-user experience.

In an IT lead world, incumbents generally win because they have the existing relationship with the IT organization.

I think people are always able to achieve more than they think they can. While that’s cliche, I don’t know if managers think about that enough. You have to set your sights extremely high.

The 10% between 90% done to 100% done takes most of the time, causes most of the stress, but is all of the value.

Jeff Bezos is opening a retail store and owns a newspaper. Turns out everything we thought about the Internet is wrong.

Modularize, don’t customize. Build a platform as opposed to building all of the custom technology and custom vertical experiences.

We’re going from a world of customized software to standardized platforms.

Why we do what we do: that moment when you get to see the future on your computer screen before the rest of the world.

The benefit to building a startup is that customers don’t have the same kind of friction when they adopt new technology.

If you don’t go to every level of your company, you distance yourself from the marketplace and from your people.

The fictional treatment of biographical material – a treatment that for me is essential – is full of traps.

That is why, according to this newer psychology, Christianity has already fulfilled its biological mission, and it is impossible for the modern man to understand its original significance.

Biologically the species is the accumulation of the experiments of all its successful individuals since the beginning.

I have always had this basic biological question in terms of evolution, if the drive to evolution is to like survive.

Each child is biologically required to have a mother. Fatherhood is a well-regarded theory, but motherhood is a fact.

Electrons and possibly x-rays to be able to get the architecture of these molecules, the molecular structures themselves, of very complex biological systems. That’s the ultimate goal.

Think about the whole world of biological complex sciences. We still don’t understand the way a protein folds the way it does.

The history of making war with biological weapons begins in mythology, in ancient oral traditions that preserved records of actual events and ideas of the era before the invention of written histories.