For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICKAgain the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
More Francis Crick Quotes
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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Since I essentially knew nothing, I had an almost completely free choice.
FRANCIS CRICK -
There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
FRANCIS CRICK -
Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
FRANCIS CRICK -
Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
FRANCIS CRICK -
I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
FRANCIS CRICK -
My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
FRANCIS CRICK -
A theory should not attempt to explain all the facts, because some of the facts are wrong.
FRANCIS CRICK -
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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Evolution is cleverer than you are.
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We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
FRANCIS CRICK -
A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
FRANCIS CRICK -
You can do reverse engineering, but you can’t do reverse hacking.
FRANCIS CRICK -
Chance is the only source of true novelty.
FRANCIS CRICK