We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
FRANCIS CRICKChristianity may be OK between consenting adults in private but should not be taught to young children.
More Francis Crick Quotes
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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A busy life is a wasted life.
FRANCIS CRICK -
It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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Since I essentially knew nothing, I had an almost completely free choice.
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God is a hacker, not an engineer.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
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One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.
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You can do reverse engineering, but you can’t do reverse hacking.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
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A man who is right every time is not likely to do very much.
FRANCIS CRICK -
Chance is the only source of true novelty.
FRANCIS CRICK -
Evolution is cleverer than you are.
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
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You’re nothing but a pack of neurons.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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Exact knowledge is the enemy of vitalism.
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
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It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
FRANCIS CRICK -
Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
FRANCIS CRICK -
Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
FRANCIS CRICK -
The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
FRANCIS CRICK