In my experience most mathematicians are intellectually lazy.
FRANCIS CRICKSince I essentially knew nothing, I had an almost completely free choice.
More Francis Crick Quotes
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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Christianity may be OK between consenting adults in private but should not be taught to young children.
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If revealed religions have revealed anything it is that they are usually wrong.
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It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
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It seems likely that most if not all the genetic information in any organism is carried by nucleic acid – usually by DNA, although certain small viruses use RNA as their genetic material.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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Exact knowledge is the enemy of vitalism.
FRANCIS CRICK -
When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
FRANCIS CRICK -
Since I essentially knew nothing, I had an almost completely free choice.
FRANCIS CRICK -
It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
FRANCIS CRICK -
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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You’re nothing but a pack of neurons.
FRANCIS CRICK -
A theory should not attempt to explain all the facts, because some of the facts are wrong.
FRANCIS CRICK -
A man who is right every time is not likely to do very much.
FRANCIS CRICK -
You can do reverse engineering, but you can’t do reverse hacking.
FRANCIS CRICK -
Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
FRANCIS CRICK -
In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
FRANCIS CRICK -
Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
FRANCIS CRICK