If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
FRANCIS CRICKWe are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
More Francis Crick Quotes
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
FRANCIS CRICK -
Since I essentially knew nothing, I had an almost completely free choice.
FRANCIS CRICK -
If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICK -
My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
FRANCIS CRICK -
You’re nothing but a pack of neurons.
FRANCIS CRICK -
Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
FRANCIS CRICK -
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
FRANCIS CRICK -
A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
FRANCIS CRICK -
You can do reverse engineering, but you can’t do reverse hacking.
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
FRANCIS CRICK