For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICKYou’re nothing but a pack of neurons.
More Francis Crick Quotes
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If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
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Chance is the only source of true novelty.
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In my experience most mathematicians are intellectually lazy.
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If revealed religions have revealed anything it is that they are usually wrong.
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God is a hacker, not an engineer.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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Exact knowledge is the enemy of vitalism.
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It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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A man who is right every time is not likely to do very much.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
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Evolution is cleverer than you are.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
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Since I essentially knew nothing, I had an almost completely free choice.
FRANCIS CRICK