Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
FRANCIS CRICKI also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
More Francis Crick Quotes
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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It seems likely that most if not all the genetic information in any organism is carried by nucleic acid – usually by DNA, although certain small viruses use RNA as their genetic material.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
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Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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A man who is right every time is not likely to do very much.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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Evolution is cleverer than you are.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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It is notoriously difficult to define the word living.
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The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
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It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
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If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
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You’re nothing but a pack of neurons.
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Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
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Exact knowledge is the enemy of vitalism.
FRANCIS CRICK -
I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
FRANCIS CRICK -
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
FRANCIS CRICK -
We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
FRANCIS CRICK