“When a man plays a woman in a dress, you’re halfway there. It’s inherently funny. When a woman plays a man, for whatever reason, it’s not that instant kind of funny.”

I think part of picking where you live in New York is accepting who you are. Really looking at yourself and going, ‘Yeah, I’m not cool enough for the West Village.’

I want every day to be the most boring news day ever. I want every day to be about spelling bee champions and baby basketball. It’s better to have no comedy material than a horrific news day.

It will never be perfect, but perfect is overrated. Perfect is boring on live TV.

When actors are too good-looking, I can’t memorize them. For example, I have never seen a picture of Sienna Miller where I didn’t say, “That girl’s pretty. Who is that?

I have no affinity for animals. I don’t hate animals and I would never hurt an animal; I just don’t actively care about them.

I was a little excited but mostly blorft. “Blorft” is an adjective I just made up that means ‘Completely overwhelmed but proceeding as if everything is fine and reacting to the stress with the torpor of a possum.’ I have been blorft every day for the past seven years.

For my first show at ‘SNL’, I wrote a Bill Clinton sketch, and during our read-through, it wasn’t getting any laughs.

According to a new study, women in satisfying marriages are less likely to develop cardiovascular diseases than unmarried women. So don’t worry, lonely women, you’ll be dead soon.

Politics and prostitution have to be the only jobs where inexperience is considered a virtue.

I got a fan letter on the back of a prison menu. And I remember thinking, ‘Well, they get pie. It’s not so bad. They get pie on the weekends.’ I want to say blueberry and also a Boston cream pie. Not so bad.

When humor works, it works because it’s clarifying what people already feel. It has to come from someplace real.

If you want to make an audience laugh, you dress a man up like an old lady and push her down the stairs. If you want to make comedy writers laugh, you push an actual old lady down the stairs.

Confidence is 10 percent hard work and 90 percent delusion, just thinking foolishly that you will be able to do what you want to do

MAKE STATEMENTS also applies to us women: Speak in statements instead of apologetic questions. No one wants to go to a doctor who says, “I’m going to be your surgeon? I’m here to talk to you about your procedure?

An interim government was set up in Afghanistan. It included two women, one of whom was Minister of Women’s Affairs. Man, who’d she have to show here ankles to to get that job?

I’m not that good looking… nobody is that good looking. I have seen a lot of movie stars, and maybe four are amazing looking. The rest have a team of gay guys who make it happen.