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Since I essentially knew nothing, I had an almost completely free choice.

Francis Crick

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
FRANCIS CRICK

Detail Evidence Ideas Ourselves Science Type
We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
FRANCIS CRICK

Human Kind Man Reproduction Run
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
FRANCIS CRICK

Correction Group Place Reading Right Start
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
FRANCIS CRICK

Evidence Freedom Science System
You can do reverse engineering, but you can’t do reverse hacking.
FRANCIS CRICK

Professional Technology Yourself
How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
FRANCIS CRICK

Division Group Science
The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
FRANCIS CRICK

Dangerous Death Fight Himself Ideas Thinking
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
FRANCIS CRICK

Biology Code Direction Evidence Science
Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
FRANCIS CRICK

Life Science Understand
It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
FRANCIS CRICK

Brain Complication Detail Essential Place See Understand Universe
For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICK

Oneself Simplicity Thinking
Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
FRANCIS CRICK

Argument Experiment Impression Negative Possible
Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
FRANCIS CRICK

Action Biology Problem
My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
FRANCIS CRICK

Function Prejudice Science Study Understand Yourself
Exact knowledge is the enemy of vitalism.
FRANCIS CRICK

Enemy Knowledge One Liner
A man who is right every time is not likely to do very much.
FRANCIS CRICK

Accomplishment Man Right Time

Since I essentially knew nothing, I had an almost completely free choice.

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Since I essentially knew nothing, I had an almost completely free choice.

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