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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

Francis Crick

We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
FRANCIS CRICK

Experiment Myself Result Science Team Work
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
FRANCIS CRICK

Evidence Freedom Science System
A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
FRANCIS CRICK

Criticism Friendship Goodness Measurement Science Value
Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
FRANCIS CRICK

Believe Earth Help Need. Mental Old
Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
FRANCIS CRICK

Argument Experiment Impression Negative Possible
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
FRANCIS CRICK

Detail Evidence Ideas Ourselves Science Type
A theory should not attempt to explain all the facts, because some of the facts are wrong.
FRANCIS CRICK

Explanation Fact Theory Wrong
If revealed religions have revealed anything it is that they are usually wrong.
FRANCIS CRICK

Religion Reveal Wrong
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
FRANCIS CRICK

Agreement Comparison Measurement Production
One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.
FRANCIS CRICK

Country Earth Myself Opinion People Scare World
The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
FRANCIS CRICK

Dangerous Death Fight Himself Ideas Thinking
Chance is the only source of true novelty.
FRANCIS CRICK

Chance Novel True
There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
FRANCIS CRICK

Average Difficult Paper Reading Science Understand
Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
FRANCIS CRICK

Determination Listen Sound Structure Try
Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
FRANCIS CRICK

Biology Design Evolution Mindset Science See
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
FRANCIS CRICK

Correction Group Place Reading Right Start

It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

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