It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
FRANCIS CRICKA good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
More Francis Crick Quotes
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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Chance is the only source of true novelty.
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Avoid the temptation to work so hard that there is no time left for serious thinking.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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It is notoriously difficult to define the word living.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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A knowledge of the true age of the Earth and of the fossil record makes it impossible for any balanced intellect to believe in the literal truth of every part of the Bible in the way that fundamentalists do.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
FRANCIS CRICK