It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
FRANCIS CRICKIt seems likely that most if not all the genetic information in any organism is carried by nucleic acid – usually by DNA, although certain small viruses use RNA as their genetic material.
More Francis Crick Quotes
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
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Avoid the temptation to work so hard that there is no time left for serious thinking.
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A theory should not attempt to explain all the facts, because some of the facts are wrong.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
FRANCIS CRICK