How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
FRANCIS CRICKThere is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
More Francis Crick Quotes
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Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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Avoid the temptation to work so hard that there is no time left for serious thinking.
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It is notoriously difficult to define the word living.
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You can do reverse engineering, but you can’t do reverse hacking.
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The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
FRANCIS CRICK -
Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
FRANCIS CRICK -
It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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Exact knowledge is the enemy of vitalism.
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A man who is right every time is not likely to do very much.
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One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.
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Christianity may be OK between consenting adults in private but should not be taught to young children.
FRANCIS CRICK