It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
FRANCIS CRICKIt now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
FRANCIS CRICKA comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
FRANCIS CRICKIf the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
FRANCIS CRICKIt has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
FRANCIS CRICKFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICKMy own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
FRANCIS CRICKIn the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
FRANCIS CRICKIt is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
FRANCIS CRICKProtein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
FRANCIS CRICKThere is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
FRANCIS CRICKA knowledge of the true age of the Earth and of the fossil record makes it impossible for any balanced intellect to believe in the literal truth of every part of the Bible in the way that fundamentalists do.
FRANCIS CRICKAvoid the temptation to work so hard that there is no time left for serious thinking.
FRANCIS CRICKThe balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
FRANCIS CRICKAgain the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
FRANCIS CRICKThere is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
FRANCIS CRICKWe have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
FRANCIS CRICK