“Just just because there are flaws in aircraft design that doesn’t mean flying carpets exist.”

Yes. I’m a doctor, an epidemiologist, and lots of my professional colleagues flip back and forth between industry and medical roles. I know them; they are not bad people. But it is possible for good people in bad systems to do things that inflict enormous harm.

Children can be disgusting, and often they can develop extraordinary talents, but I’m yet to meet any child who can stimulate his carotid arteries inside his ribcage.

Amazing things happen when you pull individual pieces of information together into larger linked datasets: meaning emerges, as you produce facts from figures.

I hope that you will be asked to participate in a trial at some stage in your disease

The placebo effect is one of the most fascinating things in the whole of medicine. It’s not just about taking a pill, and your performance and your pain getting better. It’s about our beliefs and expectations. It’s about the cultural meaning of a treatment.

I spend a lot of time talking to people who disagree with me – I would go so far as to say that it’s my favourite leisure activity.

Data is the fabric of the modern world: just like we walk down pavements, so we trace routes through data, and build knowledge and products out of it.

These corporations run our culture, and they riddle it with bullshit.

If I was writing a lifestyle book it would have the same advice on every page, and you’d know it all already.

I’ve detected myself using a new rule of thumb: if you don’t link to primary sources, I just don’t trust you.

The plural of anecdotes is not data

Eat lots of fruit and vegetables, and live your whole life in every way as well as you can: exercise regularly as part of your daily routine, avoid obesity, don’t drink too much, don’t smoke, and don’t get distracted from the real, basic, simple causes of ill health.

But as we will see, even these things are hard to do on your own, and in reality require wholesale social and political changes.

There is this peculiar blind spot in the culture of academic medicine around whether withholding trial results is research misconduct. People who work in any industry can reinforce each others’ ideas about what is okay.

I agree, the world would be a better place if doctors were less enthusiastic about adopting very new drugs.

One of the things I always found interesting is the same tricks are used to distort medicine in all of those domains.

No one can hate you with more intensity than someone who used to love you.

Awards don’t really mean much.

A free press can only exist where there is private control over the means of production

Fairness does not mean everyone gets the same. Fairness means everyone gets what they need.

A writer is a person who cares what words mean, what they say, how they say it.

Worship means reverence and humility. It means revering your real self and humbling delusions. If you can wipe out evil desires and harbor good thoughts, even if nothing shows, it’s worship. Such form is its real form.

The most fortunate of persons is he who has the most means to satisfy his vagaries.

I wanted to be as close as I could to the Really Real, and I’ll capitalize both of those R’s, because God is a word that means different things to different people, but we might all agree it’s what is most real.