“If I was writing a lifestyle book it would have the same advice on every page, and you’d know it all already.”

There is this peculiar blind spot in the culture of academic medicine around whether withholding trial results is research misconduct. People who work in any industry can reinforce each others’ ideas about what is okay.

I agree, the world would be a better place if doctors were less enthusiastic about adopting very new drugs.

One of the things I always found interesting is the same tricks are used to distort medicine in all of those domains.

I think you’ll find it’s a bit more complicated than that.

I think you’ll find it’s a bit more complicated than that.

Science has authority not because of white coats or titles, but because of precision and transparency: you explain your theory, set out your evidence, and reference the studies that support your case.

Teaching needs an ecosystem that supports evidence-based practice. It will need better systems to disseminate the results of research more widely, but also a better understanding of research, so that teachers can be critical consumers of evidence.

You cannot reason people out of a position that they did not reason themselves into.

There are many differences between medicine and teaching, but they have much in common. Both involve craft and personal expertise, learned through experience; but both can be informed by the experience of others.

Transparency and detail are everything in science.

As it is a major component of blood, water is vital for transporting oxygen to the brain. Heaven forbid that your blood should dry out.

Real science is all about critically appraising the evidence for somebody else’s position.

And if, by the end [of this book], you reckon you might still disagree with me, then I offer you this: you’ll still be wrong, but you’ll be wrong with a lot more panache and flair than you could possibly manage right now.

Just just because there are flaws in aircraft design that doesn’t mean flying carpets exist.

Positive findings are around twice as likely to be published as negative findings. This is a cancer at the core of evidence-based medicine.

You are a placebo responder. Your body plays tricks on your mind. You cannot be trusted.