“Biologists must constantly keep in mind that what they see was not designed, but rather evolved.”

For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.

You can do reverse engineering, but you can’t do reverse hacking.

It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.

It seems likely that most if not all the genetic information in any organism is carried by nucleic acid – usually by DNA, although certain small viruses use RNA as their genetic material.

When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.

If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.

It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.

How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.

It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.

It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.

Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.

Since I essentially knew nothing, I had an almost completely free choice.

A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.

Avoid the temptation to work so hard that there is no time left for serious thinking.

Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.

God is a hacker, not an engineer.

For my part, I would say that the male sperm and seeds of plants have been penetrated so far that there is nothing further to discover in this great secret, but I could err in my opinion.

DNA was my only gold rush. I regarded DNA as worth a gold rush.

Religion is an attempt to get control over the sensory world, in which we are placed, by means of the wish-world, which we have developed inside us as a result of biological and psychological necessities. But it cannot achieve its end.

Biological men have no place in women’s sports.

If the history-deniers who doubt the fact of evolution are ignorant of biology, those who think the world began less than ten thousand years ago are worst than ignorant, they are the deluded to the point of perversity.

If there is a human moral to be drawn, it is that we must teach our children altruism, for we cannot expect it to be part of their biological nature.

And you are made of a hundred trillion cells. We are, each of us, a multitude.

Our entire biological system, the brain, and the Earth itself, work on the same frequencies.