Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
FRANCIS CRICKFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
More Francis Crick Quotes
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
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A theory should not attempt to explain all the facts, because some of the facts are wrong.
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Evolution is cleverer than you are.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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You can do reverse engineering, but you can’t do reverse hacking.
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There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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In my experience most mathematicians are intellectually lazy.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
FRANCIS CRICK