Avoid the temptation to work so hard that there is no time left for serious thinking.
FRANCIS CRICKAlmost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
More Francis Crick Quotes
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
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It is notoriously difficult to define the word living.
FRANCIS CRICK -
Free will is located in or near the anterior cingulate sulcus.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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Exact knowledge is the enemy of vitalism.
FRANCIS CRICK







