The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
FRANCIS CRICKThe balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
More Francis Crick Quotes
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Evolution is cleverer than you are.
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The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
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It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us.
FRANCIS CRICK -
Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
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Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
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Biologists must constantly keep in mind that what they see was not designed, but rather evolved.
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If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
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If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
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It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clinches into place.
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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
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Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
FRANCIS CRICK