Protein synthesis is a central problem for the whole of biology, and that it is in all probability closely related to gene action.
FRANCIS CRICKA final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
More Francis Crick Quotes
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Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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Christianity may be OK between consenting adults in private but should not be taught to young children.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICK -
There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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One of the most frightening things in the Western world, and in this country in particular, is the number of people who believe in things that are scientifically false. If someone tells me that the earth is less than 10,000 years old, in my opinion he should see a psychiatrist.
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
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Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
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Exact knowledge is the enemy of vitalism.
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Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
FRANCIS CRICK