You’re nothing but a pack of neurons.
FRANCIS CRICKIt would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
More Francis Crick Quotes
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A busy life is a wasted life.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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Rather than believe that Watson and Crick made the DNA structure, I would rather stress that the structure made Watson and Crick.
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I also suspect that many workers in this field [molecular biology] and related fields have been strongly motivated by the desire, rarely actually expressed, to refute vitalism.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
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A man who is right every time is not likely to do very much.
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Avoid the temptation to work so hard that there is no time left for serious thinking.
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There is no form of prose more difficult to understand and more tedious to read than the average scientific paper.
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We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
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It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
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Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
FRANCIS CRICK