It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
FRANCIS CRICKIt would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
More Francis Crick Quotes
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Evolution is cleverer than you are.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
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A theory should not attempt to explain all the facts, because some of the facts are wrong.
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When you start in science, you are brainwashed into believing how careful you must be, and how difficult it is to discover things. There’s something that might be called the ‘graduate student syndrome’; graduate students hardly believe they can make a discovery.
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It is notoriously difficult to define the word living.
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In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death.
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A man who is right every time is not likely to do very much.
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure”.
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Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
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A knowledge of the true age of the Earth and of the fossil record makes it impossible for any balanced intellect to believe in the literal truth of every part of the Bible in the way that fundamentalists do.
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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
FRANCIS CRICK