“Just just because there are flaws in aircraft design that doesn’t mean flying carpets exist.”

The placebo effect is one of the most fascinating things in the whole of medicine. It’s not just about taking a pill, and your performance and your pain getting better. It’s about our beliefs and expectations. It’s about the cultural meaning of a treatment.

I spend a lot of time talking to people who disagree with me – I would go so far as to say that it’s my favourite leisure activity.

Data is the fabric of the modern world: just like we walk down pavements, so we trace routes through data, and build knowledge and products out of it.

These corporations run our culture, and they riddle it with bullshit.

If I was writing a lifestyle book it would have the same advice on every page, and you’d know it all already.

I’ve detected myself using a new rule of thumb: if you don’t link to primary sources, I just don’t trust you.

The plural of anecdotes is not data

Eat lots of fruit and vegetables, and live your whole life in every way as well as you can: exercise regularly as part of your daily routine, avoid obesity, don’t drink too much, don’t smoke, and don’t get distracted from the real, basic, simple causes of ill health.

But as we will see, even these things are hard to do on your own, and in reality require wholesale social and political changes.

There is this peculiar blind spot in the culture of academic medicine around whether withholding trial results is research misconduct. People who work in any industry can reinforce each others’ ideas about what is okay.

I agree, the world would be a better place if doctors were less enthusiastic about adopting very new drugs.

One of the things I always found interesting is the same tricks are used to distort medicine in all of those domains.

I think you’ll find it’s a bit more complicated than that.

I think you’ll find it’s a bit more complicated than that.

Science has authority not because of white coats or titles, but because of precision and transparency: you explain your theory, set out your evidence, and reference the studies that support your case.

Teaching needs an ecosystem that supports evidence-based practice. It will need better systems to disseminate the results of research more widely, but also a better understanding of research, so that teachers can be critical consumers of evidence.

The difficulty of literature is not to write, but to write what you mean; not to affect your reader, but to affect him precisely as you wish.

Remember, weapons of mass destruction don’t mean missiles.

I like the cold weather. It means you get work done.

You can tell on-stage when a joke’s starting to lose its pop. It doesn’t mean people don’t want to hear it anymore; it means I don’t want to do it anymore. Because I want to move on to something that has a knee-jerk reaction just like you get when you tell somebody a joke that they’ve never heard.

There are very few things impossible in themselves; and we do not want means to conquer difficulties so much as application and resolution in the use of means.

In computing, the mean time to failure keeps getting shorter.

Nothing is impossible; there are ways that lead to everything, and if we had sufficient will we should always have sufficient means. It is often merely for an excuse that we say things are impossible.

Somebody the other day had a review, called me ‘America’s reprobate.’ And I don’t even know what that means, but I kinda like the way it sounds.