The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
FRANCIS CRICKExact knowledge is the enemy of vitalism.
More Francis Crick Quotes
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For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the – class as having one too few.
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Exploratory research is really like working in a fog. You don’t know where you’re going. You’re just groping. Then people learn about it afterwards and think how straightforward it was.
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Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
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An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going.
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Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
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We are sometimes asked what the result would be if we put four +’s in one gene. To answer this my colleagues have recently put together not merely four but six +’s.
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We have to take away from humans in the long run their reproductive autonomy as the only way to guarantee the advancement of mankind.
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God is a hacker, not an engineer.
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In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign.
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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.
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The dangerous man is the one who has only one idea, because then he’ll fight and die for it.
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A busy life is a wasted life.
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Chance is the only source of true novelty.
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Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
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A good scientist values criticism almost higher than friendship: no, in science criticism is the height and measure of friendship.
FRANCIS CRICK