It is changes that are chiefly responsible for diseases, especially the greatest changes, the violent alterations both in the seasons and in other things. (:)…regimen and temperature, and one period of life to another.
It is the same thing which makes us mad or delirious, inspires us with dread and fear, whether by night or by day, brings us sleeplessness, inopportune mistakes, aimless anxieties, absent-mindedness and acts that are contrary to habit.
