“Consider the Lichen. Lichens are just about the hardiest visible organisms on Earth, but the least ambitious.”

I come from Des Moines. Someone had to.

Because we humans are big and clever enough to produce and utilize antibiotics and disinfectants, it is easy to convince ourselves that we have banished bacteria to the fringes of existence.

I’m not a natural story-teller. Put a keyboard in front of me and I’m fine, but stand me up in front of an audience and I’m actually quite shy and reserved.

Everything that has ever lived, plant or animal, dates its beginning from the same primordial twitch. At some point in an unimaginably distant past, some little bag of chemicals fidgeted to life. It absorbed some nutrients, gently pulsed, had a brief existence.

If you can imagine a man having a vasectomy without anesthetic to the sound of frantic sitar-playing, you will have some idea of what popular Turkish music is like.

I understand now, in a way I never did before, the colossal scale of the world. I found patience and fortitude that I didn’t know I had. I discovered an America that millions of people scarcely know exists. I made a friend. I came home.

Cheapness is a great virtue.

Making English grammar conform to Latin rules is like asking people to play baseball using the rules of football.

To understand what anyone is saying to us we must separate these noises into words and the words into sentences so that we might in our turn issue a stream of mixed sounds in response.

And a really good story because he was this kid who grew up essentially as an orphan, you know, had a tough life, and then he became the most successful baseball player ever. But he was also a really good guy.

America is a great disappointment to me. As I said in one of my books, other societies create civilisations; we build shopping malls.

That’s 270 million people with 206 bones each – will only be about 50 bones, one-quarter of a complete skeleton. That’s not to say, of course, that any of these bones will ever actually be found.

I mused for a few moments on the question of which was worse, to lead a life so boring that you are easily enchanted, or a life so full of stimulus that you are easily bored.

Protons give an atom its identity, electrons its personality.

Boston’s freeway system is insane. It was clearly designed by a person who had spent his childhood crashing toy trains.

Beulah has a husband?’ I know. It’s a miracle. There can’t be more than two people on the planet who’d be willing to sleep with her, and here we are both in the same town.

For years, more women were steered toward the studio or toward being a reporter. If that’s what you want to do and that’s what you love – by all means, go do it. That’s OK to be ambitious and do things that are out of the norm if that’s the route you want to take.

I’ve always liked working really hard and then doing nothing in particular. So, consequently, I didn’t overexpose myself; I guess I maintained a kind of mystery. I wasn’t ambitious.

Saving our planet requires you to be ambitious in what you aim, and, equally, in how hard you work to reach your goal.

Among all kinds of Writing, there is none in which Authors are more apt to miscarry than in Works of Humour, as there is none in which they are more ambitious to excel.

When men call women ambitious they mean pushy.

Vastly ambitious individuals who had become so effectively powerful because of their ability to remain invisible while operating behind the national scenery.

“The Diagnosis” is by far my most ambitious book. I such great hopes for it… there was so much I wanted to do with the book. I was extremely insecure about it for several years.

Still being ambitious to want to play on the record, I was a mediocre keyboard player. And uh, I seized the opportunity and played the organ.