“I don’t wear a mask, I don’t have a suit. It’s not some CG double or a stunt double. The suffering the character [Doctor Strange ] goes through is immense!”

[Scott Derrickson] is terrific, really sharp on the details, and he’s not afraid to go to dark places.

[Sherlock Holmes] has moved from being someone who was sociopathic, work-obsessed and slightly amoral, into being someone who has a certain degree of a private life, which is very, very private, with The Woman, or Irene Adler.

I’m sort of focused on my long-term goal of carving out a career that’s for life, rather than being a flash in the pan.

It’s great for the people who supported me early on to see the success I’m enjoying.

Those are more universal things than some of the characters I play, who are slightly sociopathic. I keep reminding people I can do ordinary.

Even in cerebral roles that are seemingly intelligent and nothing else, I think it’s so important to wrap your characterization in a physical form as well.

I’m quite sensitive to people noticing me. There are times when I’m relaxed, then others when it does make me self-conscious.

I realised quite early on that, although I wasn’t trying to make a career speciality of it, I was playing slightly asexual, sociopathic intellectuals.

I had to kiss it [ playing Hamlet] goodbye because Marvel have to plot things for the next three, four years.

Doctors and nurses do crazy hours and keep an ideal afloat through the love and care that they have for their craft and their patients and the institution of the NHS. We should be very proud of it.

The biggest lesson Stephen Strange learns in this film is it’s not all about him.

There’s so much in the 21st century that is stymied by bureaucracy and mediocrity and committee.

There are other people who don’t mind shouting from the pulpit and being judged for it, and they do a hell of a lot of good – real, on-the-ground, life-changing good. So I think it can sometimes be a balancing act.

Do I like being thought of as attractive? I don’t know anyone on Earth who doesn’t, but I do find it funny.

If I’d had fame early on, I’d have been able to abuse it in the way that a young man should.

I wanted to take the audience on a journey where that transition was funny and awkward. It’s the same cynicism that [Strange] has.

I’m a football coach. I’m not a doctor … They don’t call plays, I don’t do surgeries. We have a great deal here.

I know patients who bring a dozen roses to the doctor’s office. And, boy, the next visit, nobody forgets that. You come in and hey – ‘Here’s the lady who brought the roses’ vs. ‘Here’s the lung cancer.’

Even though Doctor Strange is an established character, when you’re doing an origin story there’s a lot of room for manoeuvre.

Doctors are busy playing God when so few of us have the qualifications. And besides, the job is taken.

It’s an interesting arc. You start with a character [Doctor Strange] who’s likeable and charming but very arrogant and distant. He’s funny but you can see there are massive holes in his life. It’s a very painful transition and all that he becomes is tested so quickly and violently.

That cactus went right through my eye. It left my eye flat. They took me to a doctor, and he said, ‘We’ll have to take the eye out.’ …I fought like a tiger. I said, ‘No! Leave the eye alone.

There’s a heroic amount of effort that goes into making him [Doctor Strange] a superhero by the end of the film.

I wish medical schools helped us to analyze our healthy and unhealthy reasons for becoming doctors.