“The goal of scientific physicians in their own science … is to reduce the indeterminate. Statistics therefore apply only to cases in which the cause of the facts observed is still indeterminate.”

In science, the best precept is to alter and exchange our ideas as fast as science moves ahead.

We must remain, in a word, in an intellectual disposition which seems paradoxical, but which, in my opinion, represents the true mind of the investigator. We must have a robust faith and yet not believe.

True science teaches us to doubt and, in ignorance, to refrain.

Those who do not know the torment of the unknown cannot have the joy of discovery.

The doubter is a true man of science: he doubts only himself and his interpretations, but he believes in science.

Obervation is a passive science, experimentation is an active science.

The investigator should have a robust faith – and yet not believe.

The fact that knowledge endlessly recedes as the investigator is about to grasp it is what constitutes at the same time his torment and happiness.

If I had to define life in a single phrase, I should clearly express my thought of throwing into relief one characteristic which, in my opinion, sharply differentiates biological science. I should say: life is creation.

First causes are outside the realm of science.

The great experimental principle, then, is doubt, that philosophic doubt which leaves to the mind its freedom and initiative, and from which the virtues most valuable to investigators in physiology and medicine are derived.

A great discovery is a fact whose appearance in science gives rise to shining ideas, whose light dispels many obscurities and shows us new paths.

A discovery is generally an unforeseen relation not included in theory.

Well-observed facts, though brought to light by passing theories, will never die; they are the material on which alone the house of science will at last be built.

Particular facts are never scientific; only generalization can establish science.

Men who believe too firmly in their theories, do not believe enough in the theories of others. So these despisers of their fellows make experiments only to destroy a theory, instead of to seek the truth.

Self-inquiry is the process and the goal also. ‘I am’ is the goal and the final reality. To hold to it with effort is self-inquiry. When spontaneous and natural it is realization.

I guess my goal is to design my own walker. The walkers with the big tennis balls, no one wants to use those. I would rather crawl down the street in New York City than use those.

Tidying is just a tool, not the final destination. The true goal should be to establish the lifestyle you want most once your house has been put in order.

I don’t care who scores the goals, I’m going to leave my human beingness on the field!

Four goals in (16) minutes. Literally I don’t even know how that happens especially in a World Cup final.

Aim high, aim at the highest, and all lower aims are thereby achieved. It is looking below on the stormy sea of differences that makes you sink. Look up, beyond these and see the One Glorious Real, and you are saved.

One should aim not at being possible to understand, but at being impossible to misunderstand.

A small laugh startled me and I looked over to see her actually smiling. Making her do that more often was a new goal.